D81
Header — not billableCombined immunodeficiencies
The ICD-10 code for combined immunodeficiencies is D81.
D81 is a non-billable header code. It groups related conditions but cannot be used on its own for reimbursement — select one of the 10 more specific codes below.
Clinical notes
Excludes1 (not coded here)
An Excludes1 note is a pure exclusion: the excluded condition and this code should never be reported together, because the two conditions cannot occur at the same time (e.g. a congenital form vs. an acquired form of the same disease).
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Documentation support
General coding-documentation guidance — not a substitute for payer-specific requirements or professional coding judgment.
- •This is a non-billable header code. Documentation must support a more specific child code before this diagnosis can be reported on a claim.
- •Confirm the excluded condition(s) listed above are not also present — Excludes1 conditions cannot be coded together with this one.
- •As a general rule, code to the highest level of specificity supported by the documentation in the medical record.
Child codes under D81
- D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesis
- D81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
- D81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
- D81.3Adenosine deaminase [ADA] deficiencynon-billable header
- D81.4Nezelof's syndrome
- D81.5Purine nucleoside phosphorylase [PNP] deficiency
- D81.6Major histocompatibility complex class I deficiency
- D81.7Major histocompatibility complex class II deficiency
- D81.8Other combined immunodeficienciesnon-billable header
- D81.9Combined immunodeficiency, unspecified
Related codes in this category
- D80Immunodeficiency with predominantly antibody defectsnon-billable header
- D82Immunodeficiency associated with other major defectsnon-billable header
- D83Common variable immunodeficiencynon-billable header
- D84Other immunodeficienciesnon-billable header
- D86Sarcoidosisnon-billable header
- D89Other disorders involving the immune mechanism, not elsewhere classifiednon-billable header
- D81Combined immunodeficienciesnon-billable header